The FDA is moving every National Drug Code (NDC) to one 12-digit format. The rule takes effect on March 7, 2033[1]. Use this checklist to see what your pharmacy needs to ask, test and teach before then.
An NDC is the number that identifies a drug product and its package. Today the FDA assigns NDCs that are 10 digits long, in more than one layout[1]. Under the final rule published on March 5, 2026, every FDA-assigned NDC will be 12 digits in one layout: 6 digits for the company, 4 for the product and 2 for the package[2].
On March 7, 2033, the FDA will start assigning 12-digit NDCs and will convert every existing 10-digit NDC to the 12-digit format[1]. The FDA asks pharmacies, payers and the rest of the supply chain to start preparing as soon as possible[1].
Seen a different date? Go by the FDA. The dates on this page come from the FDA's own page on the final rule[1].
Every item is checked. Keep your provider answers on file and check in again each year.
Your answers stay in this browser tab. Nothing is saved or sent anywhere.
Each item is a question to ask or a test to run. Most of the answers will come from the companies you already work with.
The software you use to fill, label and bill prescriptions, plus anything else in the store that stores a drug number.
The price files, catalogs and invoices you receive from the companies you buy from.
How prescriptions are billed to insurance plans and how you prove a claim was right later.
What prints on prescription labels and what your scanners read.
The people who check, fill and bill prescriptions every day.
RXLens reviews every claim, every day, and keeps the proof you need when a plan audits you. Talk with us about getting ready for the NDC change.
Or reach us at rxlens@ayaanis.com or 215-666-0376.
This checklist is general information to help you plan. It is not legal or regulatory advice. Check with your providers, your plans and the FDA for requirements that apply to your pharmacy.
